| Cat. No. |
Product Name |
Information |
| PC-28138 |
GD136
H1R/H4R antagonist
|
GD136 (GD-136) is a potent, selective dual histamine H1 and H4 receptors (H1R/H4R) ligand / antagonist with pKi of 7.61 and 7.93 (hH1R/hH4R), shows >100-fold selectivity over hH2R and hH3R. |
| PC-28137 |
Olopatadine hydrochloride
H1R antagonist
|
Olopatadine hydrochloride (AL-4943A, KW-4679) is an antiallergic/antihistaminic agent that inhibits mast cell mediator release and possesses histamine H1 receptor (H1R) antagonist activity with Ki of 31.6 nM, shows much lower affinities for H2 receptors and H3 receptors (Ki>50 uM). |
| PC-28136 |
Olopatadine
H1R antagonist
|
Olopatadine (AL-4943A, KW-4679) is an antiallergic/antihistaminic agent that inhibits mast cell mediator release and possesses histamine H1 receptor (H1R) antagonist activity with Ki of 31.6 nM, shows much lower affinities for H2 receptors and H3 receptors (Ki>50 uM). |
| PC-28131 |
Adriforant hydrochloride
Histamine H4 antagonist
|
Adriforant hydrochloride (PF-3893787, ZPL-3893787) is a potent and selective histamine H4 receptor (H4R) antagonist with binding Ki of 2.4 nM. |
| PC-28130 |
GD134
H1R/H4R antagonist
|
GD134 (GD-134) is a potent, selective dual histamine H1 and H4 receptors (H1R/H4R) ligand / antagonist with pKi of 7.54 and 7.67 (hH1R/hH4R), shows 5-fold selectivity over hH3R and high selectivity over hH2R. |
| PC-27866 |
LINS01022
H3R antagonist
|
LINS01022 is a high affinity, selective histamine H3 receptor (H3R) antagonist with pKi of 8.2, >1000-fold selective over H4R, exhibits potent antiproliferative effect against 4T1 and MDA-MB-231 TNBC cell lines. |
| PC-26243 |
Thioperamide
H3R antagonist
|
Thioperamide (MR-12842) is a potent, selective, orally available, brain penetrant inverse agonist / antagonist of histamine H3-receptor (H3R) with Ki of 4.3 nM for inhibition of [3H]histamine release, inhibits [3H]histamine synthesis of KI of 31 nM. |
| PC-23473 |
JNJ-7777120
H4R antagonist
|
JNJ-7777120 (JNJ 7777120) is potent and selective histamine H4 receptor (H4R) antagonist with Ki of 4.5 nM (hH4R), >1000-fold selectivity over H1, H2, or H3 receptors. |
| PC-20926 |
JNJ 10191584
H4R antagonist
|
JNJ 10191584 (VUF6002) is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor. |
| PC-20925 |
JNJ 10191584 maleate
Histamine H4 antagonist
|
JNJ-10191584 (VUF6002) maleate is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor. |
| PC-49738 |
UR-MB-69
H2 receptor agonist
|
UR-MB-69 is a potent agonist of histamine H2 receptor (H2R) dopamine receptor D3R with pKi of 8.69 and 8.06, respectively. |
| PC-49737 |
UR-MB-158
H2 receptor agonist
|
UR-MB-158 is a a potent, selective H2 receptor agonist. |
