JNJ 10191584 | Histamine H4 antagonist | Probechem Biochemicals

Chemical Structure : JNJ 10191584

CAS No.: 73903-17-0

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JNJ 10191584 (JNJ-10191584, VUF6002)

货号: PC-20926Not For Human Use, Lab Use Only.

JNJ 10191584 (VUF6002) is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

JNJ 10191584 (VUF6002) is a potent, highly selective, orally active histamine H(4) receptor antagonist with binding Ki of 26 nM, 540-fold selectivity to H4 receptor over H3 receptor.
JNJ 10191584 (VUF6002) shows inhibitory effects to chemotaxis of eosinophils and mast cells with IC50 values of 530 nM and 138 nM, respectively.
JNJ 10191584 (10-100 mg/kg p.o., b.i.d.) caused a dose-dependent reduction in macroscopic damage, inhibition of the TNBS-provoked elevation of both colonic myeloperoxidase and tumour necrosis factor-alpha (TNF-alpha), and a reduction in the histologically assessed increase in mucosal and submucosal thickness and neutrophil infiltration.

物理化学性质&存储条件

分子量	278.74
分子式	C13H15ClN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(5-chloro-1H-benzo[d]imidazol-2-yl)(4-methylpiperazin-1-yl)methanone

参考文献

1. Varga C, et al. Eur J Pharmacol. 2005 Oct 17;522(1-3):130-8.

2. Venable JD, et al. J Med Chem. 2005 Dec 29;48(26):8289-98.

JNJ 10191584 (JNJ-10191584, VUF6002)

生物&药学活性

物理化学性质&存储条件

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JNJ 10191584 (JNJ-10191584, VUF6002)

生物&药学活性

物理化学性质&存储条件

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