Adriforant hydrochloride (PF-3893787, ZPL-3893787)

Chemical Structure : Adriforant hydrochloride

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货号: PC-28131Not For Human Use, Lab Use Only.

Adriforant hydrochloride (PF-3893787, ZPL-3893787) is a potent and selective histamine H4 receptor (H4R) antagonist with binding Ki of 2.4 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Adriforant hydrochloride (PF-3893787, ZPL-3893787) is a potent and selective histamine H4 receptor (H4R) antagonist with binding Ki of 2.4 nM.
Adriforant (PF-3893787, ZPL 3893787) has an IC50 of 1.16 nM on human native isolated eosinophils assessing actin polymerisation.
Adriforant (PF-3893787, ZPL 3893787) exhibits anti-inflammatory activity.

物理化学性质&存储条件

分子量	371.74
分子式	C13H25Cl3N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine hydrochloride

参考文献

1. Mowbray CE, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602.