JNJ-7777120 | H4R antagonist | Probechem Biochemicals

Chemical Structure : JNJ-7777120

CAS No.: 459168-41-3

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JNJ-7777120 (JNJ7777120)

货号: PC-23473Not For Human Use, Lab Use Only.

JNJ-7777120 (JNJ 7777120) is potent and selective histamine H4 receptor (H4R) antagonist with Ki of 4.5 nM (hH4R), >1000-fold selectivity over H1, H2, or H3 receptors.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

JNJ-7777120 (JNJ 7777120) is potent and selective histamine H4 receptor (H4R) antagonist with Ki of 4.5 nM (hH4R), >1000-fold selectivity over H1, H2, or H3 receptors.
JNJ-7777120 (JNJ 7777120) is equipotent against the human, mouse, and rat receptors.
JNJ 7777120 blocks histamine-induced chemotaxis and calcium influx in mouse bone marrow-derived mast cells.
JNJ 7777120 blocks the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice.
JNJ 7777120 significantly blocks neutrophil infiltration in a mouse zymosan-induced peritonitis model.

物理化学性质&存储条件

分子量	277.75
分子式	C14H16ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine

参考文献

1. Thurmond RL, et al. J Pharmacol Exp Ther. 2004 Apr;309(1):404-13.

2. Lim HD, et al. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21.

3. Ling P, et al. Br J Pharmacol. 2004 May;142(1):161-71.

JNJ-7777120 (JNJ7777120)

生物&药学活性

物理化学性质&存储条件

参考文献

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JNJ-7777120 (JNJ7777120)

生物&药学活性

物理化学性质&存储条件

参考文献

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