| Cat. No. |
Product Name |
Information |
| PC-25804 |
BKS-112
HDAC6 inhibitor
|
BKS-112 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 42.98 nM, 126-fold selective over HDAC1. |
| PC-25614 |
ITF-6475
HDAC6 inhibitor
|
ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes. |
| PC-25412 |
SYSUP007
HDAC inhibitor
|
SYSUP007 is a derivative of the FTO inhibitor rhein, and HDAC and SGK1 inhibitor, inhibits the proliferation of human GBM cells. |
| PC-25411 |
Parthenolide
HDAC1 inhibitor, USP10 inhibitor
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs. |
| PC-25393 |
OCP-001
HDAC1 inhibitor
|
OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation. |
| PC-25178 |
J22352
HDAC6 inhibitor
|
J22352 is a potent, highly selective HDAC6 inhibitor with IC50 of 4.7 nM, >2000-fold selective for HDAC6 than for class I HDACs (HDAC1, HDAC2 and HDAC3), and with little activity against HDAC8. |
| PC-25167 |
class I HDACs inhibitor JT86
HDAC1 inhibitor
|
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2. |
| PC-25166 |
DAC-001
HDAC1 activator
|
DAC-001 is a small molecule, cell-active activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, displayes significant protection against DNA breaks. |
| PC-25165 |
DAC-003
HDAC1 activator
|
DAC-003 is a small molecule activator of HDAC1, exhibits dose-dependent activation of HDAC1 in vitro in a microfluidics-based assay at 5-10 uM, DAC-003 is protective against oxidative stress. |
| PC-25163 |
Exifone
HDAC1 activator
|
Exifone is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM. |
| PC-25162 |
Chlopynostat
HDAC1 inhibitor
|
Chlopynostat is a potent, selective HDAC1 inhibitor with IC50 of 67 nM, with no activity against HDAC6/8/10 (IC50>1000 nM). |
| PC-25161 |
CBUD-1001
HDAC1 inhibitor
|
CBUD-1001 is specific small molecule HDAC1 inhibitor with IC50 of 28.1 nM, inhibits HDAC2 and HDAC3 with IC50 values of 158 nM and 404 nM, respectively. |
