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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Entinostat
Entinostat

Chemical Structure : Entinostat

CAS No.: 209783-80-2

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Entinostat (MS-275, SNDX-275, MS275, SNDX275)

货号: PC-42902Not For Human Use, Lab Use Only.

Entinostat (MS275) is a potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Entinostat (MS275) is a potent and selective class I HDACs inhibitor with IC50 of 243/453/248 nM for HDAC1/2/3.
Entinostat (MS275) shows no inhibition on HDAC8/4/5/7/9/6/10 (IC50>10 uM).
Entinostat (MS275) induces accumulation of p21WAF1/CIP1 and gelsolin in K562 cell.
Entinostat (MS275) reduce S-phase cells and induce G1-phase cells in A2780 cell.

物理化学性质&存储条件

分子量 376.4085
分子式 C21H20N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester

参考文献

1. Saito A, et al. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4592-7.

2. Lauffer BE, et al. J Biol Chem. 2013 Sep 13;288(37):26926-43.

3. Rosato RR, et al. Cancer Res. 2003, 63(13), 3637-3645.

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