TMP269 | class IIa HDAC inhibitor | Probechem Biochemicals

Chemical Structure : TMP269

CAS No.: 1314890-29-3

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TMP269 (TMP-269, TMP 269)

货号: PC-45462Not For Human Use, Lab Use Only.

TMP269 (TMP 269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

TMP269 (TMP 269) is a potent and selective class IIa HDAC inhibitor with IC50s of 126/80/36/19 nM for HDAC4/5/7/9.
TMP269 is less potent or no inhibition for others HDAC isoforms (>2 uM).
TMP269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation in IEC-18 cells.

物理化学性质&存储条件

分子量	514.5195
分子式	C25H21F3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	Benzamide, N-[[tetrahydro-4-(4-phenyl-2-thiazolyl)-2H-pyran-4-yl]methyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-

参考文献

1. Lobera M, et al. Nat Chem Biol. 2013 May;9(5):319-25.

2. Sinnett-Smith J, et al. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.

3. Kikuchi S, et al. Leukemia. 2015 Sep;29(9):1918-27.

TMP269 (TMP-269, TMP 269)

生物&药学活性

物理化学性质&存储条件

参考文献

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TMP269 (TMP-269, TMP 269)

生物&药学活性

物理化学性质&存储条件

参考文献

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