Belinostat | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Belinostat

CAS No.: 866323-14-0

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Belinostat (PXD101, PX105684, PXD-101)

货号: PC-42469Not For Human Use, Lab Use Only.

Belinostat (PXD101, PX105684) is a potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).

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25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg	￥2380	In stock
250 mg		Get quote

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生物&药学活性

Belinostat (PXD101, PX105684) is a potent HDAC inhibitor with IC50 of 27 nM (HeLa cell extracts).
Belinostat (PXD101, PX105684) inhibits histone deacetylase activity in cell lysates with IC50 of 9-100 nM, increases the acetylation of histone H4 and induces apoptosis in tumor cell lines.
Belinostat (PXD101, PX105684) inhibits the growth of a range of human tumor cell lines in vitro (IC50=0.2-3.4 uM).
Belinostat (PXD101, PX105684) shows antitumor activity in vivo with no apparent toxicity.

物理化学性质&存储条件

分子量	318.3477
分子式	C15H14N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-, (2E)-

参考文献

1. Plumb JA, et al. Mol Cancer Ther. 2003 Aug;2(8):721-8.

2. Qian X, et al. Mol Cancer Ther. 2006 Aug;5(8):2086-95.

3. Buckley MT, et al. J Transl Med. 2007 Oct 12;5:49.

Belinostat (PXD101, PX105684, PXD-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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Belinostat (PXD101, PX105684, PXD-101)

生物&药学活性

物理化学性质&存储条件

参考文献

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