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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Vorinostat
Vorinostat

Chemical Structure : Vorinostat

CAS No.: 149647-78-9

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Vorinostat (SAHA, Suberoylanilide hydroxamic acid, MK-0683)

货号: PC-42465Not For Human Use, Lab Use Only.

Vorinostat (SAHA) is a potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.

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250 mg ￥980 In stock
500 mg ￥1380 In stock
1 g ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vorinostat (SAHA) is a potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
Vorinostat (SAHA) inhibits cell growth, induces terminal differentiation and prevents the formation of tumours in mice models.

物理化学性质&存储条件

分子量 264.3202
分子式 C14H20N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 100 mg/mL
Chemical Name/SMILES

Octanediamide, N1-hydroxy-N8-phenyl-

参考文献

1. Richon VM, et al. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

2. Finnin MS, et al. Nature. 1999 Sep 9;401(6749):188-93.

3. Vrana JA, et al. Oncogene. 1999 Nov 25;18(50):7016-25.

4. Richon VM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10014-9.

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