| Cat. No. |
Product Name |
Information |
| PC-72457 |
Azoffluxin
Cdr1 inhibitor
|
Azoffluxin (CMLD012336) is a bis-benzodioxolylindolinone that synergizes with fluconazole against C. auris through the inhibition of efflux pump Cdr1, thus increasing intracellular fluconazole levels. |
| PC-72423 |
GW461484A
Yck2 inhibitor
|
GW461484A (GW-461484A) is a potent small molecule capable of restoring caspofungin sensitivity, inhibits Yck2 kinase in C. albicans, originally discovered as an inhibitor of human p38α with IC50 of 150 nM. |
| PC-38031 |
Rezafungin
Antifungal
|
Rezafungin (CD101) is a long-acting novel echinocandin possesses potent antibiofilm activity against early and mature candida albicans biofilms. |
| PC-38016 |
Echinocandin B
|
Echinocandin B is a cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus nidulans var. echinulatus with specific anti-yeast activity. |
| PC-35452 |
Fosmanogepix
Gwt1 inhibitor
|
Fosmanogepix (APX001, E1211) is a novel antifungal agent, the prodrug form of Manogepix, which inhibits the fungal protein Gwt1. |
| PC-63228 |
ML316
Mir1 inhibitor
|
ML316 is a specific antifungal agent that fungal-selectively inhibits the mitochondrial phosphate carrier Mir1, exhibits potent antifungal activity against the moderatelyazole-resistant C. albicans strain CaCi-2 with MIC of 0.05 ug/ml. |
| PC-62615 |
PC945
Antifungal
|
Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively. |
| PC-62607 |
PC1244
Fungal CYP51A/CYP51B inhibitor
|
PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM. |
| PC-61753 |
VT-1161
Fungal CYP51 inhibitor
|
VT-1161 (Oteseconazole) is a potent, highly-selective, and oral fungal CYP51 inhibitor with Kd of ≤ 39 nM. |
| PC-61752 |
VT-1598
Fungal CYP51B inhibitor
|
VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM. |
| PC-70346 |
Filastatin
Antifungal
|
Filastatin is a small molecule inhibitor that inhibits adhesion of C. albicans to polystyrene. |
| PC-70224 |
F-901318
Fungal DHODH inhibitor
|
F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM. |
