ISFP10

Chemical Structure : ISFP10

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货号: PC-23892Not For Human Use, Lab Use Only.

ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme.

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生物&药学活性

ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme.
ISFP10 inhibits AfPGMC353 with IC50 of 4 uM, 50- and 25-fold higher IC50 values for HsPGM.
ISFP10 can also significantly reduce Pmpgm2 activity in vitro.
ISFP10 displays antifungal activity in a concentration-dependent manner against C. albicans and C. glabrata.

物理化学性质&存储条件

分子量	311.36
分子式	C17H13NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl 4-(3-oxoisothiazol-2(3H)-yl)benzoate

参考文献

1. Yan K, et al. J Biol Chem. 2022 Jun;298(6):102003.

2. Kottom TJ, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0075623.

ISFP10

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物理化学性质&存储条件

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ISFP10

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物理化学性质&存储条件

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