| Cat. No. |
Product Name |
Information |
| PC-27772 |
FX0685
Antifungal
|
FX0685 is a triazole antifungal agent with potent activity against fluconazole-resistant Candida albicans, shows potent inhibitory activity against fungal cytochrome P450 protein CYP51. |
| PC-27769 |
NT-a9
Antifungal
|
NT-a9 is an analogue of isavuconazole with strong antifungal activities in vitro and in vivo, shows a wide range of activities against several pathogenic fungi in vitro, including Cryptococcus neoformans, Cryptococcus gattii, Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis with MICs of 0.002-1 ug/mL. |
| PC-27585 |
Inz-5
Fungal complex III inhibitor
|
Inz-5 is a fungal-specific indazole derivative inhibitor of Candida albicans (C. albicans) complex III (CIII) with IC50 of 24 nM in UQH2:cyt c oxidoreductase assays. |
| PC-27214 |
SYP-14288
Fungicide
|
SYP-14288 is a novel fungicide acts as an uncoupler of oxidative phosphorylation against Phytophthora capsici, inhibits ATP synthesis of the pathogen. |
| PC-26831 |
F2F-202
HDAC6 inhibitor
|
F2F-202 is a a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.1 nM, shows great selectivity over HDAC1 and selected as a representative of nuclear HDACs (422-fold), shows synergistic activity in combination with the azole antifungal voriconazole. |
| PC-25620 |
Isoxazole 1
CnAcs1 inhibitor
|
Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL. |
| PC-24646 |
Tps1 inhibitor 4456dh
Fungal Tps1 inhibitor
|
Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus. |
| PC-23892 |
ISFP10
AfPGM inhibitor
|
ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme. |
| PC-23298 |
Manogepix
Gwt1 inhibitor
|
Manogepix (APX001A, E1210) is a potent antifungal agent targeting the fungal glycosylphosphatidylinositol acyltransferase Gwt1, demonstrates potent in vitro activity against clinical isolates of both Candida (Candida spp, MIC50/90=0.008/0.12 mg/L) and Aspergillus species. |
| PC-22712 |
MBX-7591
Antifungal agent
|
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles. |
| PC-21852 |
NP-BTA
C. albicans Gln4 inhibitor
|
NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth. |
| PC-21530 |
Phenamacril
Myosin 5 inhibitor
|
Phenamacril (Fungicide JS399-19) is a specific inhibitor of myosin5 protein (Myo5), inhibits ergosterol biosynthesis pathway and exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates. |
