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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-NT-a9
NT-a9

Chemical Structure : NT-a9

CAS No.: 2071279-81-5

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NT-a9

货号: PC-27769Not For Human Use, Lab Use Only.

NT-a9 is an analogue of isavuconazole with strong antifungal activities in vitro and in vivo, shows a wide range of activities against several pathogenic fungi in vitro, including Cryptococcus neoformans, Cryptococcus gattii, Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis with MICs of 0.002-1 ug/mL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NT-a9 is an analogue of isavuconazole with strong antifungal activities in vitro and in vivo, shows a wide range of activities against several pathogenic fungi in vitro, including Cryptococcus neoformans, Cryptococcus gattii, Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis with MICs of 0.002-1 ug/mL.
NT-a9 exhibits excellent efficacy against C. neoformans, with a MIC as low as 0.002 ug/mL.
NT-a9 treatment resulted in changes in the sterol contents in C. neoformans, similarly to fluconazole.
NT-a9 significantly prolonged the survival times of mice compared with the survival times of the control group or the isavuconazole-, fluconazole-, or amphotericin B-treated groups.
NT-a9 also significantly reduced the fungal burdens in brains and lungs, while fluconazole and amphotericin B only reduced the fungal burden in lungs.

物理化学性质&存储条件

分子量 480.40
分子式 C22H17F5N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)butan-2-ol

参考文献

1. Lu RY, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01628-19.

2. Zhu S, et al. Antimicrob Agents Chemother. 2026 Aug 5:e0076826.

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