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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-Y18501
Y18501

Chemical Structure : Y18501

CAS No.: 2410627-32-4

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Y18501 (Y-18501)

货号: PC-28091Not For Human Use, Lab Use Only.

Y18501 is a smalll molecule oxysterol-binding protein (OSBP) inhibitor, shows strong inhibitory activity against Pseudoperonospora cubensis with EC50 of 0.001-11.785 ug/mL for 159 Ps. cubensis isolates.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Y18501 is a smalll molecule oxysterol-binding protein (OSBP) inhibitor, shows strong inhibitory activity against Pseudoperonospora cubensis with EC50 of 0.001-11.785 ug/mL for 159 Ps. cubensis isolates.
Y18501 shows good control efficacy on cucumber downy mildew (CDM) in the green house and in the field.
Y18501 could effectively inhibit different development stages of P. cubensis, especially for sporangiophore production, sporangial production, mycelium extension, and elongation of germ tube.
Y18501 shows excellent protective and curative activities against P. cubensis. acropetal systemic mobility in the cucumber leaves, and could be taken up and translocated to the upper leaves more effectively from the lower leaves than from the roots.

物理化学性质&存储条件

分子量 536.60
分子式 C27H26F2N6O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(4-(5-(2,6-difluorophenyl)-4,5-dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-1-yl)-2-(3-ethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)ethan-1-one

参考文献

1. Xue Z, et al. J Agric Food Chem. 2023 Mar 22;71(11):4510-4520.

2. Wang B, et al. Pestic Biochem Physiol. 2023 Aug;194:105415.

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