F2F-202

Chemical Structure : F2F-202

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货号: PC-26831Not For Human Use, Lab Use Only.

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生物&药学活性

F2F-202 is a a potent and selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.1 nM, shows great selectivity over HDAC1 and selected as a representative of nuclear HDACs (422-fold), shows synergistic activity in combination with the azole antifungal voriconazole.
F2F-202 shows synergistic activity in combination with the azole antifungal voriconazole (VRC) through the modulation of fungal histone deacetylase Hda1.
F2F-202 shows growth inhibition against the azole-resistant C. albicans ATCC 10231 strain in combination with VRC, combined with a significant reduction of yeast-to-hyphae morphological transition.
Synergistic combination F2F-202/VRC affects the expression of key genes regulated by Hda1 activity and involved in morphogenesis, namely, Nrg1, Als1, and Hpw1.
Synergistic combination F2F-202/VRC counteracts the VRC-induced upregulation of Erg11, a gene involved in C. albicans azole resistance.

物理化学性质&存储条件

分子量	643.79
分子式	C36H45N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl ((2S,3R)-3-hydroxy-4-(3-(4-(hydroxycarbamoyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-1-phenylbutan-2-yl)carbamate

参考文献

1. Barone S, et al. ACS Infect Dis. 2026 May 22. doi: 10.1021/acsinfecdis.6c00195.

F2F-202

生物&药学活性

物理化学性质&存储条件

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F2F-202

生物&药学活性

物理化学性质&存储条件

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