| Cat. No. |
Product Name |
Information |
| PC-24828 |
Micafungin
Antifungal, UBE2M inhibitor
|
Micafungin (FK463) is an echinocandin antifungal drug which can inhibit 1,3-beta-D-glucan synthase, inhibits the production of 1,3-β-D-glucan in fungal cell walls, acts as a neddylation inhibitor that targets Ubiquitin-conjugating enzyme 2M (UBE2M). |
| PC-24827 |
Collismycin A
Iron chelator
|
Collismycin A (CMA, SF2738A) is a microbial product produced by Streptomyces sp. with anti-proliferative activity against cancer cells, acts as a specific iron chelator and binds both Fe(II) and Fe(III) ions and forms a 2:1 chelator-iron complex with a redox-inactive center. |
| PC-24826 |
SF2768
Copper chelator, Antifungal
|
SF2768 (RK-276A) is a diisonitrile antibiotic and specific copper chelator, exhibits potent antifungal activity against C. albicans with IC50 of 0.01 uM. |
| PC-24659 |
PanK inhibitor MNS
Fungal PanK inhibitor
|
PanK inhibitor MNS is a broad-spectrum antifungal, fungal-selective inhibitor of PanK with IC50 of 1.13 μM and 17.74 μM against CaCab1p and AfPanKp respectively, directly engages and inhibits PanK to block CoA production. |
| PC-24646 |
Tps1 inhibitor 4456dh
Fungal Tps1 inhibitor
|
Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus. |
| PC-23892 |
ISFP10
AfPGM inhibitor
|
ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme. |
| PC-23890 |
MN-I-157
Yck2 inhibitor
|
MN-I-157 is a specific inhibitor of fungal casein kinase 1 (CK1) family member Yck2 with sub-micromolar potencey. |
| PC-23889 |
YK-I-02
Yck2 inhibitor
|
YK-I-02 is a specific inhibitor of fungal casein kinase 1 (CK1) family member Yck2 with sub-micromolar potencey, 8- to 20-fold selectivity over CK1α but less than 3-fold selectivity over p38α. |
| PC-23301 |
APX2020
Gwt1 inhibitor
|
APX2020 is a novel potent small molecule inhibitor of fungal Gwt1, has MIC of 0.016-0.031 ug/ mL against C. neoformans, C. gattii, Candida albicans. |
| PC-23300 |
APX2096
Gwt1 inhibitor
|
APX2096 is the prodrug of APX2039, which is a novel potent small molecule inhibitor of fungal Gwt1, reduces fungal burden in vivo. |
| PC-23299 |
APX2039
Gwt1 inhibitor
|
APX2039 is a novel potent small molecule inhibitor of fungal Gwt1, has MIC of 0.008-0.031 ug/ mL against C. neoformans, C. gattii, Candida albicans. |
| PC-23298 |
Manogepix
Gwt1 inhibitor
|
Manogepix (APX001A, E1210) is a potent antifungal agent targeting the fungal glycosylphosphatidylinositol acyltransferase Gwt1, demonstrates potent in vitro activity against clinical isolates of both Candida (Candida spp, MIC50/90=0.008/0.12 mg/L) and Aspergillus species. |
