F-901318 (Olorofim) | Fungal DHODH inhibitor | Probechem Biochemicals

Chemical Structure : F-901318

CAS No.: 1928707-56-5

加入收藏

F-901318 (Olorofim, F901318)

货号: PC-70224Not For Human Use, Lab Use Only.

F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.

规格	价格	库存
5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7880	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

F-901318 (Olorofim) is a novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM.
F-901318 (Olorofim) shows little inhibition of human DHODH (>100 uM).
F-901318 (Olorofim) displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp.

物理化学性质&存储条件

分子量	498.562
分子式	C28H27FN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide

参考文献

1. Oliver JD, et al. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304.

2. Wiederhold NP, et al. J Antimicrob Chemother. 2017 Mar 15. doi: 10.1093/jac/dkx065.

3. Buil JB, et al. J Antimicrob Chemother. 2017 Jun 10. doi: 10.1093/jac/dkx177.

F-901318 (Olorofim, F901318)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

F-901318 (Olorofim, F901318)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.