iKIX1 | CgGal11A-CgPdr1 inhibitor | Probechem Biochemicals

Chemical Structure : iKIX1

CAS No.: 656222-54-7

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iKIX1 (iKIX 1, iKIX-1)

货号: PC-60335Not For Human Use, Lab Use Only.

iKIX1 is a small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
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生物&药学活性

iKIX1 is a small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM.
iKIX1 blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection.
iKIX1 is a novel therapeutic strategy in fungal infectious disease.

物理化学性质&存储条件

分子量	303.161
分子式	C10H8Cl2N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide

参考文献

1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9.

iKIX1 (iKIX 1, iKIX-1)

生物&药学活性

物理化学性质&存储条件

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iKIX1 (iKIX 1, iKIX-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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