Quilseconazole | Fungal CYP51 inhibitor | Probechem Biochemicals

Chemical Structure : Quilseconazole

CAS No.: 1340593-70-5

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Quilseconazole (VT-1129, VT1129)

货号: PC-60051Not For Human Use, Lab Use Only.

A novel selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
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生物&药学活性

Quilseconazole (VT-1129) is a selective, orally available fungal CYP51 (lanosterol 14-α-demethylase) inhibitor.
Quilseconazole displays greater selectivity for fungal enzyme than for mammalian CYP450 compared to the approved azole class of antifungal drugs.
Quilseconazole inhibits C. albicans and T. rubrum with MIC of <0.001 ug/mL, also demonstrated potent activities against Cryptococcusspecies as demonstrated by low MIC50 and MIC90 values.

物理化学性质&存储条件

分子量	513.376
分子式	C22H14F7N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(trifluoromethoxy)phenyl]pyridin-2-yl}propan-2-ol

参考文献

1. Hoekstra WJ, et al. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8.

2. Lockhart SR, et al. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31.

3. Warrilow AG, et al. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8.

4. Nielsen K, et al. Med Mycol. 2017 Jun 1;55(4):453-456.

Quilseconazole (VT-1129, VT1129)

生物&药学活性

物理化学性质&存储条件

参考文献

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Quilseconazole (VT-1129, VT1129)

生物&药学活性

物理化学性质&存储条件

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