Itraconazole |CAS:84625-61-6 Probechem Biochemicals

Chemical Structure : Itraconazole

CAS No.: 84625-61-6

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Itraconazole (R51211)

货号: PC-45319Not For Human Use, Lab Use Only.

Itraconazole (R51211) is a triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase, inhibits hedgehog signaling pathway with IC50 of 800 nM.

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500 mg	￥1580	In stock
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生物&药学活性

Itraconazole (R51211) is a triazole antifungal agent for fungal infections via inhibition of lanosterol 14α-demethylase, inhibits hedgehog signaling pathway with IC50 of 800 nM.
Itraconazole also has been shown to inhibit both the hedgehog signaling pathway and angiogenesis.
Itraconazole also is a core-1 beta1,3-galactosyltransferase (C1GALT1) inhibitor that directly binds C1GALT1 and promotes its proteasomal degradation.

物理化学性质&存储条件

分子量	705.6334
分子式	C35H38Cl2N8O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 7.3 mg/mL
Chemical Name/SMILES	3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-, rel-

参考文献

1. Kim J, et al. Cancer Cell. 2010 Apr 13;17(4):388-99.

2. Aftab BT, et al. Cancer Res. 2011 Nov 1;71(21):6764-72.

3. Chong CR, et al. ACS Chem Biol. 2007 Apr 24;2(4):263-70.

Itraconazole (R51211)

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物理化学性质&存储条件

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Itraconazole (R51211)

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