Posaconazole hydrate |CAS:1198769-38-8 Probechem Biochemicals

Chemical Structure : Posaconazole hydrate

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Posaconazole hydrate (SCH-56592 hydrate)

货号: PC-45196Not For Human Use, Lab Use Only.

Posaconazole hydrate is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.

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生物&药学活性

Posaconazole hydrate is a triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.

物理化学性质&存储条件

分子量	718.7927
分子式	C37H44F2N8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)- (hydrate)(1:1)

参考文献

1. Benaim G, et al. J Med Chem. 2006 Feb 9;49(3):892-9.

2. Sabatelli F, et al. Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15.

Posaconazole hydrate (SCH-56592 hydrate)

生物&药学活性

物理化学性质&存储条件

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Posaconazole hydrate (SCH-56592 hydrate)

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物理化学性质&存储条件

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