Erg6 inhibitor H55

Chemical Structure : Erg6 inhibitor H55

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货号: PC-20789Not For Human Use, Lab Use Only.

Erg6 inhibitor H55 is an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase (Erg6), potently inhibits C. albicans hyphal formation in multiple cultural conditions.

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50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Erg6 inhibitor H55 is an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase (Erg6), potently inhibits C. albicans hyphal formation in multiple cultural conditions.
H55 monotherapy exhibits therapeutic efficacy in mouse models of azole-resistant candidiasis.
H55 treatment increases the accumulation of zymosterol, the substrate of C-24 sterol methyltransferase (Erg6).

物理化学性质&存储条件

分子量	517.45
分子式	C26H21BrN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(4-(4-bromophenyl)-2-(phenylimino)thiazol-3(2H)-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one

参考文献

1. Jin X, et al. Cell Chem Biol. 2023 May 2:S2451-9456(23)00116-2.