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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-MMV688766
MMV688766

Chemical Structure : MMV688766

CAS No.: 904508-14-1

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MMV688766 (MMV 688766)

货号: PC-49414Not For Human Use, Lab Use Only.

MMV688766 (MMV 688766) is a small molecule displaying broad-spectrum fungicidal activity through perturbation of lipid homeostasis, inhibits the growth of four geographically distinct C. auris clades with MIC80 of 12.5-50 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MMV688766 (MMV 688766) is a small molecule displaying broad-spectrum fungicidal activity through perturbation of lipid homeostasis, inhibits the growth of four geographically distinct C. auris clades with MIC80 of 12.5-50 uM.
    MMV688766 inhibits the growth of C. albicans, Candida glabrata, and C. neoformans with comparable potency to that observed against C. auris with MIC80 of 12.5-25 uM.
    MMV688766 disrupts fatty acid homeostasis without directly inhibiting the canonical fatty acid synthase (FAS), induces accumulation of lipid droplets in C. auris and C. albicans in a dose-dependent manner.
    Treatment of C. auris with MMV688766 (25 uM) leads to a reduction in fatty acid and sphingolipid intermediate levels as a result of delayed fatty acids synthesis.
    Loss of function of the transcriptional regulator HAL9 confers resistance to MMV688766, in part through the upregulation of the lipid-binding chaperone HSP12, a response that appears to assist in tolerating MMV688766-induced stress.

    物理化学性质&存储条件

    分子量 369.724
    分子式 C17H11ClF3NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(4-chlorophenyl)-3-(trifluoromethyl)isoxazol-5-yl)-5-methoxyphenol

    参考文献

    1. Emily Puumala, et al. mBio. 2022 Oct 27;e0273022.

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