ATI-2307 (T-2307)

Chemical Structure : ATI-2307

加入收藏

货号: PC-21197Not For Human Use, Lab Use Only.

ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ATI-2307 (T-2307) is a pentamidine-like compound with antifungal activity, selectively targets fungal mitochondria via a fungal-specific transporter that is not present in mammalian cells.
ATI-2307 shows a broad spectrum of activity against many fungal pathogens including Candida spp, Aspergillus spp., and C. neoformans.
ATI-2307 shows IC50 of 0.01-0.06 ug/mL against C. neoformans clinical isolates from Uganda.
ATI-2307 demonstrates significant fungicidal activity at dosages between 1 and 2 mg/kg/d, and is superior to fluconazole and similar to amphotericin B treatment in rabbit model cryptococcal meningoencephalitis (CM).
ATI-2307 disrupts the mitochondrial membrane potential and inhibits the respiratory chain complexes of fungi-it thus represents a new mechanism for direct antifungal action.

物理化学性质&存储条件

分子量	437.59
分子式	C25H35N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{3-[1-(3-{4-[amino(imino)-methyl]phenoxy}propyl)piperidin-4-yl]propoxy}benzamidine

参考文献

1. Gerlach ES, et al. Front Cell Infect Microbiol. 2021 Jun 23;11:695240.

2. Giamberardino CD, et al. Antimicrob Agents Chemother. 2023 Sep 20:e0081823.

ATI-2307 (T-2307)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ATI-2307 (T-2307)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.