NP-BTA | C. albicans Gln4 inhibitor | Probechem Biochemicals

Chemical Structure : NP-BTA

CAS No.: 544420-99-7

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NP-BTA (N-pyrimidinyl-β-thiophenylacrylamide)

货号: PC-21852Not For Human Use, Lab Use Only.

NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.

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10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
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生物&药学活性

NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.
Met496 of Gln4 is a critical residue for NP-BTA's species-selective target engagement and potency.
NP-BTA demonstrates efficacy against diverse C. albicans strains.
NP-BTA potently inhibits Gln4 enzyme-catalyzed aminoacylation of synthetic tRNAGln with IC50 of 108 nM.
NP-BTA does not inhibit translation in mammalian cells.
NP-BTA displays therapeutic potential in C. elegans candidiasis and mouse dermatomycosis models.
NP-BTA potently inhibits tRNA amino-acylation by fungal Gln4 through an allosteric mechanism that is unique amongst all other reported tRNA synthetase inhibitors.

物理化学性质&存储条件

分子量	231.27
分子式	C11H9N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-pyrimidinyl-β-thiophenylacrylamide

参考文献

1. Puumala E, et al. Cell Chem Biol. 2024 Feb 20:S2451-9456(24)00046-1.

NP-BTA (N-pyrimidinyl-β-thiophenylacrylamide)

生物&药学活性

物理化学性质&存储条件

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NP-BTA (N-pyrimidinyl-β-thiophenylacrylamide)

生物&药学活性

物理化学性质&存储条件

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