| Cat. No. |
Product Name |
Information |
| PC-60290 |
SB-218078
CHK1 inhibitor
|
SB-218078 (SB218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM. |
| PC-60286 |
PD-321852
CHK1 inhibitor
|
PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM. |
| PC-60285 |
XL-844
Chk1/Chk2 inhibitor
|
XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively. |
| PC-60284 |
PV-1115
Chk2 inhibitor
|
PV-1115 (PV1115) is a potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM, displays greater than 100 uM for Chk1 in vitro. |
| PC-60283 |
PV-1019
Chk2 inhibitor
|
PV-1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |
| PC-60282 |
NSC109555 ditosylate
Chk2 inhibitor
|
NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM. |
| PC-60280 |
VER-250840
CHK1 inhibitor
|
VER-250840 is a potent, selective, orally active Chk1 inhibitor with IC50 of < 1 nM, Ki=69 pM. |
| PC-60279 |
VER-158411
Chk1/2 inhibitor
|
VER-158411 (V-158411) is a potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively. |
| PC-60278 |
GDC-0425
CHK1 inhibitor
|
GDC-0425 (RG7602) is a potent, selective and orally active Chk1 inhibitor. |
| PC-60276 |
GDC-0575
Chk1 inhibitor
|
GDC-0575 (ARRY-575, RG7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM. |
| PC-60200 |
VRX-0466617
Chk2 inhibitor
|
VRX-0466617 (VRX0466617) is a potent and selective Chk2 inhibitor with Ki/IC50 of 11 nM/120 nM. |
| PC-45428 |
Prexasertib dihydrochloride
CHK1 inhibitor
|
Prexasertib (LY-2606368) dihydrochloride is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM. |
