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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-XL-844
XL-844

Chemical Structure : XL-844

CAS No.: 631864-00-1

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XL-844 (EXEL-9844;EXEL9844;XL844)

货号: PC-60285Not For Human Use, Lab Use Only.

XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
    XL-844 increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry.
    XL-844 significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model.

    物理化学性质&存储条件

    分子量 287.323
    分子式 C14H17N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[2-(3-aminopropoxy)phenyl]-3-pyrazin-2-ylurea

    参考文献

    1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22.

    2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10.

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