VER-158411 |CAS:1174664-88-0 Probechem Biochemicals

Chemical Structure : VER-158411

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VER-158411 (VER-00158411, V-158411)

货号: PC-60279Not For Human Use, Lab Use Only.

VER-158411 (V-158411) is a potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.

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生物&药学活性

VER-158411 (V-158411) is a potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.
VER-158411 dispalys >1,000-fold selectivity over CDK1.
VER-158411 reduces pChk1 (S296) and pChk2 (S516) levels in a concentration dependent fashion in cells treated with etoposide with IC50s of 48 nM for Chk1 and 904 nM for Chk2.
VER-158411 potentiates the cytotoxicity of chemotherapeutic agents in a variety of p53 deficient human tumor cell lines (GI50=0.5-9.5 uM) and human colon tumor xenograft models.

物理化学性质&存储条件

分子量	538.652
分子式	C31H34N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-N-(5-(5-(3-(dimethylamino)-2,2-dimethylpropoxy)-1H-indol-2-yl)-6-oxo-1,6-dihydropyridin-3-yl)-1H-pyrazole-4-carboxamide

参考文献

1. Massey AJ, et al. Oncotarget. 2015 Nov 3;6(34):35797-812.

2. Alsubhi N, et al. Mol Oncol. 2016 Feb;10(2):213-23.

3. Wayne J, et al. Oncotarget. 2016 Dec 20;7(51):85033-85048.

VER-158411 (VER-00158411, V-158411)

生物&药学活性

物理化学性质&存储条件

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VER-158411 (VER-00158411, V-158411)

生物&药学活性

物理化学性质&存储条件

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