PD-321852 |CAS: 622856-21-7 Probechem Biochemicals

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-PD-321852

Chemical Structure : PD-321852

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PD-321852 (PD 321852;PD321852)

货号: PC-60286Not For Human Use, Lab Use Only.

PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
PD-321852 potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines.
PD-321852 inhibits gemcitabine-induced Rad51 focus formation, and depletes RAD51 proteins in pancreatic cancer cells.

物理化学性质&存储条件

分子量	468.33
分子式	C24H19Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

参考文献

1. Parsels LA, et al. Mol Cancer Ther. 2009 Jan;8(1):45-54.

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PD-321852 (PD 321852;PD321852)

生物&药学活性

物理化学性质&存储条件

参考文献

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PD-321852 (PD 321852;PD321852)

生物&药学活性

物理化学性质&存储条件

参考文献

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