MU 380 |CAS:2109805-78-7 Probechem Biochemicals

Chemical Structure : MU 380

加入收藏

MU 380 (MU-380;MU380)

货号: PC-60583Not For Human Use, Lab Use Only.

MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2.
MU 380 sensitizes a variety of tumor cell lines to hydroxyurea or gemcitabine up to 10 times.
MU 380 shows extended inhibitory effects in cells, and unlike SCH900776, does not undergo in vivo N-dealkylation to the significantly less selective metabolite.
MU 380 causes higher accumulation of DNA damage in tumor cells and subsequent enhanced cell death, and is more efficacious in the A2780 xenograft mouse model.

物理化学性质&存储条件

分子量	430.233
分子式	C15H15BrF3N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-bromo-5-(piperidin-3-yl)-3-(1-(trifluoromethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine

参考文献

1. Samadder P, et al. Mol Cancer Ther. 2017 Sep;16(9):1831-1842.

MU 380 (MU-380;MU380)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MU 380 (MU-380;MU380)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.