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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)-PV1019
PV1019

Chemical Structure : PV1019

CAS No.: 1093793-05-5

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PV1019 (NSC744039, PV-1019)

货号: PC-60283Not For Human Use, Lab Use Only.

PV1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PV1019 (NSC744039) is a potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
PV1019 displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1.
PV1019 inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage.
PV1019 protects normal mouse thymocytes against ionizing radiation-induced apoptosis.

物理化学性质&存储条件

分子量 379.38
分子式 C18H17N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide

参考文献

1. Jobson AG, et al. J Pharmacol Exp Ther. 2009 Dec; 331(3):816-26.

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