Debromohymenialdisine |Cas:75593-17-8 Buy Debromohymenialdisine from ProbeChem, Global Biochemicals Supplier

Chemical Structure : Debromohymenialdisine

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Debromohymenialdisine (SKF-108753;SKF108753)

货号: PC-60291Not For Human Use, Lab Use Only.

Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.

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生物&药学活性

Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
Debromohymenialdisine also inhibits MAP kinase kinase 1 (IC50=881 nM), GSK3β (IC50=1.39 uM), and CDK5/p25 (IC50=9.12 uM), does not significantly affect ATM and ATR.
Debromohymenialdisine blocks G2 arrest in cancer cells.

物理化学性质&存储条件

分子量	245.2
分子式	C11H11N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one

参考文献

1. Curman D, et al. J Biol Chem. 2001 May 25;276(21):17914-9.

2. Saleem RS, et al. Bioorg Med Chem. 2012 Feb 15;20(4):1475-81.

3. Jobson AG, et al. Mol Pharmacol. 2007 Oct;72(4):876-84.

Debromohymenialdisine (SKF-108753;SKF108753)

生物&药学活性

物理化学性质&存储条件

参考文献

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Debromohymenialdisine (SKF-108753;SKF108753)

生物&药学活性

物理化学性质&存储条件

参考文献

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