NSC-109555 ditosylate |Cas:66748-43-4 Buy NSC-109555 ditosylate from ProbeChem, Global Biochemicals Supplier

Chemical Structure : NSC109555 ditosylate

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NSC109555 ditosylate (DDUG;NSC109555;NSC 109555)

货号: PC-60282Not For Human Use, Lab Use Only.

NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.

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生物&药学活性

NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
NSC109555 displays no effect on a range of other kinases including Chk1 (IC50>10 uM).
NSC109555 inhibits histone H1 phosphorylation (IC50=0.24 uM) and attenuates mitochondrial ATP synthesis.
NSC109555 exhibits antiproliferative activity in a number of leukemias in vivo.

物理化学性质&存储条件

分子量	752.86
分子式	C19H24N10O.2C7H8O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate

参考文献

1. Jobson AG, et al. Mol Pharmacol. 2007 Oct; 72(4):876-84.

2. Gogineni VR, et al. Cancer Lett. 2011 Dec 26;313(1):64-75.

3. Mikles-Robertson F, et al. Cancer Res. 1980 Apr;40(4):1054-61.

NSC109555 ditosylate (DDUG;NSC109555;NSC 109555)

生物&药学活性

物理化学性质&存储条件

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NSC109555 ditosylate (DDUG;NSC109555;NSC 109555)

生物&药学活性

物理化学性质&存储条件

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