Beta-secretase (BACE) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-23360	NB-360 BACE inhibitor	NB-360 is a potent, selective and brain penetrable dual BACE1/BACE2 inhibitor with IC50 of 5 nM/6 nM respectively.
PC-73095	AM-6494 BACE1 inhibitor	AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.
PC-43534	AZD3839 BACE1 inhibitor	AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D.
PC-63380	LY3202626 BACE inhibitor	LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.
PC-63377	AZ-4217 BACE1 inhibitor	AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.
PC-63290	PF-06751979 BACE1 inhibitor	PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2.
PC-43420	LY2886721 BACE1 inhibitor	LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases.
PC-61191	δ-secretase inhibitor 11 δ-secretase inhibitor	δ-secretase inhibitor 11 is a selective, orally bioactive and brain permeable δ-secretase (AEP, delta-secretase) inhibitor with IC50 of 700 nM.
PC-61044	RO5508887 BACE inhibitor	RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
PC-61042	TAK-070 BACE1 inhibitor	TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.
PC-61041	AMG-8718 BACE1 inhibitor	AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.
PC-61040	VTP-37948 BACE1 inhibitor	VTP-37948 (BI 1181181) is a potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease.

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