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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-AMG-8718
AMG-8718

Chemical Structure : AMG-8718

CAS No.: 1215868-94-2

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AMG-8718 (AMG8718)

货号: PC-61041Not For Human Use, Lab Use Only.

AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AMG-8718 is a potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin.
    BACE1 inhibitor demonstrates dose-dependent decreases in both CSF and brain Aβ levels in rat pharmacodynamic model, with significantly reduced potential for QTc elongation.

    物理化学性质&存储条件

    分子量 442.44
    分子式 C25H19FN4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (4'S)-7-(2-Fluoro-3-pyridinyl)-3-[2-(3-methyl-3-oxetanyl)ethynyl]spiro[5H-[1]benzopyrano[2,3-b]pyridine-5,4'(5'H)-oxazol]-2'-amine

    参考文献

    1. Dineen TA, et al. J Med Chem. 2014 Dec 11;57(23):9811-31.

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