AZD3839 |CAS:1227163-84-9 Probechem Biochemicals

Chemical Structure : AZD3839

CAS No.: 1227163-84-9

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AZD3839 (AZD-3839;AZD 3839)

货号: PC-43534Not For Human Use, Lab Use Only.

AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D.
AZD3839 inhibits Aβ (Aβ40 IC50=4.8 nM) and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons.
AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate.
AZD3839 demonstrates significant reduction of β-amyloid peptides in mouse brain.

物理化学性质&存储条件

分子量	431.4125
分子式	C24H16F3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-

参考文献

1. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.

2. Jeppsson F, et al. J Biol Chem. 2012 Nov 30;287(49):41245-57.

3. Aasa J, et al. Drug Metab Dispos. 2013 Jan;41(1):159-69.

4. Sparve E, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):469-78.

AZD3839 (AZD-3839;AZD 3839)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD3839 (AZD-3839;AZD 3839)

生物&药学活性

物理化学性质&存储条件

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