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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-δ-secretase inhibitor 11
δ-secretase inhibitor 11

Chemical Structure : δ-secretase inhibitor 11

CAS No.: 842964-18-5

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δ-secretase inhibitor 11 (Delta-secretase inhibitor)

货号: PC-61191Not For Human Use, Lab Use Only.

δ-secretase inhibitor 11 is a selective, orally bioactive and brain permeable δ-secretase (AEP, delta-secretase) inhibitor with IC50 of 700 nM.

规格 价格 库存 数量
10 mg ￥580 In stock
25 mg ￥980 In stock
50 mg ￥1580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

δ-secretase inhibitor 11 is a selective, orally bioactive and brain permeable δ-secretase (AEP, delta-secretase) inhibitor with IC50 of 700 nM.
δ-secretase inhibitor 11 displays 45-fold selectivity over caspases-3, and >100-fold over caspase-8, cathepsin-S and L.
δ-secretase inhibitor 11 has IC50 of 800 nM in Pala cells, reduces tau and APP cleavage, ameliorates synapse loss and augments long-term potentiation, resulting in protection of memory in mouse models of Alzheimer's disease.

物理化学性质&存储条件

分子量 220.232
分子式 C10H12N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-morpholinobenzo[c][1,2,5]oxadiazol-4-amine

参考文献

1. Zhang Z, et al. Nat Commun. 2017 Mar 27;8:14740.

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