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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-NB-360
NB-360

Chemical Structure : NB-360

CAS No.: 1262857-73-7

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NB-360 (NB360)

货号: PC-23360Not For Human Use, Lab Use Only.

NB-360 is a potent, selective and brain penetrable dual BACE1/BACE2 inhibitor with IC50 of 5 nM/6 nM respectively.

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5 mg ￥3280 In stock
10 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NB-360 is a potent, selective and brain penetrable dual BACE1/BACE2 inhibitor with IC50 of 5 nM/6 nM respectively.
NB-360 does not inhibit pepsin or the endosomal/lysosomal cathepsins D and E (IC50 > 250 μM).
NB-360 is a potent inhibitor of Aβ40 release from human APP-overexpressing CHO cells, with an IC50 of 3 nM in wtAPP CHO cells and 33 nM in SweAPP CHO cells.
NB-360 potently inhibits the release of Aβ42 (IC50: 3 nM) and sAPPβ (IC50: 4 nM) in wild-type APP CHO cells.
NB-360 is sufficient to completely block amyloid-β deposition in an APP transgenic mouse model.
NB-360 displays dose-dependent appearance of irreversibly depigmented hair, induces hair depigmentation by inhibiting PMEL17 processing in mice.

物理化学性质&存储条件

分子量 449.41
分子式 C21H19F4N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyridinecarboxamide, N-[3-[(3R,6R)-5-amino-3,6-dihydro-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl-

参考文献

1. Rueeger H, et al. J Med Chem. 2021 Apr 22;64(8):4677-4696.

2. Neumann U, et al. Br J Pharmacol. 2019 Sep;176(18):3435-3446.

3. Neumann U, et al. Mol Neurodegener. 2015 Sep 3;10:44.

4. Shimshek DR, et al. Sci Rep. 2016 Feb 25;6:21917.

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