RO5508887 (RG7129) | BACE inhibitor | Probechem Biochemicals

Chemical Structure : RO5508887

加入收藏

RO5508887 (RO 5508887, RG-7129, RG7129)

货号: PC-61044Not For Human Use, Lab Use Only.

RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
RO5508887 (RG7129) has IC50 of 18 nM in HEK293APP cells and in neuronal cultures derived from human neuronal stem cells.
RO5508887 (RG7129) significantly enhances antiamyloid effect combined with gantenerumab.

物理化学性质&存储条件

分子量	389.338
分子式	C18H14F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Cyano-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluorophenyl]amide

参考文献

1. Jacobsen H, et al. J Neurosci. 2014 Aug 27;34(35):11621-30.

RO5508887 (RO 5508887, RG-7129, RG7129)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RO5508887 (RO 5508887, RG-7129, RG7129)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.