LY3202626 | BACE inhibitor | Probechem Biochemicals

Chemical Structure : LY3202626

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LY3202626 (LY 3202626, LY-3202626)

货号: PC-63380Not For Human Use, Lab Use Only.

LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.

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生物&药学活性

LY3202626 (LY-3202626) is a highly potent, CNS-penetrant, orally available BACE inhibitor with IC50 of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.
LY3202626 causes dose-dependent reductions in CSF and plasma Aβ concentrations.
LY3202626 shows potential for the treatment of Alzheimer's disease.

物理化学性质&存储条件

分子量	498.513
分子式	C22H20F2N8O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

参考文献

1. McKinzie DL, et al. J Med Chem. 2021 Jun 24;64(12):8076-8100.
2. Lo AC, et al. J Alzheimers Dis Rep. 2021 Apr 29;5(1):321-336.

LY3202626 (LY 3202626, LY-3202626)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY3202626 (LY 3202626, LY-3202626)

生物&药学活性

物理化学性质&存储条件

参考文献

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