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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-AM-6494
AM-6494

Chemical Structure : AM-6494

CAS No.: 1874232-80-0

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AM-6494 (AM6494)

货号: PC-73095Not For Human Use, Lab Use Only.

AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AM-6494 (AM6494) is a potent and orally efficacious BACE1 inhibitor with IC50 of 0.4 nM, 47 fold selectivity over BACE2.
    Administration of AM-6494resulted in no skin/fur color change in a 13-day mouse hypopigmentation study.
    AM-6494 demonstrated robust and sustained reduction of CSF and brain Aβ40 levels in rat and monkey pharmacodynamic models.

    物理化学性质&存储条件

    分子量 473.499
    分子式 C22H21F2N5O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-((1S,5S,6S)-3-Amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4,5-difluorophenyl)-5-(prop-2-yn-1-yloxy)pyrazine-2-carboxamide

    参考文献

    1. Pettus LH, et al. J Med Chem. 2020 Mar 12;63(5):2263-2281.

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