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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-LY2886721
LY2886721

Chemical Structure : LY2886721

CAS No.: 1262036-50-9

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LY2886721 (LY 2886721, LY-2886721)

货号: PC-43420Not For Human Use, Lab Use Only.

LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY2886721 (LY-2886721) is a highly potent, selective BACE1 aspartyl protease inhibitor with IC50 of 20.3 and 10.2 nM for BACE1 and BACE2, shows no inhibition against cathepsin D, pepsin, renin, or other aspartyl proteases.
LY2886721 produces a concentration-dependent decrease in Aβ1-40 and Aβ1-42 production in HEK293Swe cells (EC50s=10 nM).
LY2886721 demonstrates robust in vivo amyloid β lowering effect in nonclinical animal models, shows similar potent and persistent amyloid β lowering was observed in plasma and lumbar in clinical trials.

物理化学性质&存储条件

分子量 390.407
分子式 C18H16F2N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 42 mg/mL
Chemical Name/SMILES

2-Pyridinecarboxamide, N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-

参考文献

1. Lahiri DK, et al. Alzheimers Dement. 2014 Oct;10(5 Suppl):S411-9.

2. May PC, et al. J Neurosci. 2015 Jan 21;35(3):1199-210.

3. Kumar D, et al. Eur J Med Chem. 2018 Mar 25;148:436-452.

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