TAK-070 |CAS:365276-12-6 Probechem Biochemicals

Chemical Structure : TAK-070

加入收藏

TAK-070 (TAK070;TAK 070)

货号: PC-61042Not For Human Use, Lab Use Only.

TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TAK-070 (TAK070) is a selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays.
TAK-070 suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells.
TAK-070 also stimulates sAPPα production with MEC of 100 nM.
TAK-070 significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM.
TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

物理化学性质&存储条件

分子量	440.02
分子式	C27H31NO.HCl.H2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-[(1,1'-biphenyl)-4-ylmethoxy]-1,2,3,4-tetrahydro-N,N-dimethyl-2-naphthalene-ethan-amine hydrochloride monohydrate

参考文献

1. Fukumoto H, et al. J Neurosci. 2010 Aug 18;30(33):11157-66.

2. Takahashi H, et al. Brain Res. 2010 Nov 18;1361:146-56.

TAK-070 (TAK070;TAK 070)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TAK-070 (TAK070;TAK 070)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.