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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Beta-secretase (BACE)-AZ-4217
AZ-4217

Chemical Structure : AZ-4217

CAS No.: 1383846-83-0

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AZ-4217 (AZ4217)

货号: PC-63377Not For Human Use, Lab Use Only.

AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AZ-4217 is a potent and selective, orally active, brain-permeable BACE1 inhibitor with IC50 of 160 pM in human SH-SY5Y cells.
    AZ-4217 demonstrates excellent in vivo efficacy, lowers amyloid deposition in 12-month-old Tg2576 mice.

    物理化学性质&存储条件

    分子量 476.555
    分子式 C30H25FN4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-5-(3-amino-4-fluoro-1-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one

    参考文献

    1. Eketjäll S, et al. J Neurosci. 2013 Jun 12;33(24):10075-84.

    2. Swahn BM, et al. J Med Chem. 2012 Nov 8;55(21):9346-61.

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