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首页-小分子抑制剂&激动剂-GPCR-mAChR

Request The Product List ofmAChR mAChR

Cat. No. Product Name Information
PC-22975

MK-7622

M1 mAChR PAM

MK-7622 is a potent, selective and CNS penetrant M1 muscarinic receptor positive allosteric modulator (PAM).
PC-20509

PIPE-359

M1 mAChR antagonist

PIPE-359 (PIPE359) is a potent, selective and brain-penetrant antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 1.8 nM and Ki of 0.14 nM (hM1R).
PC-20508

VU0415248

M1 mAChR antagonist

VU0415248 is a highly selective antagonist of muscarinic acetylcholine receptor subtype 1 (M1 mAChR) with IC50 of 0.4 uM and 0.18 uM for hM1R and rM1R, respectively.
PC-20104

Deschloroclozapine

DREADD agonist

Deschloroclozapine (DCZ) is a high-affinity and selective agonist for muscarinic-based DREADDs, shows nanomolar affinity for [3H]QNB-labeled hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
PC-49312

CHF-6366

MABA

CHF-6366 is a novel potent muscarinic antagonist and β2 agonist (MABA) with pKi of 10.2 and 11.4, respectively.
PC-49070

VU0405645

M1 Receptor PAM

VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.
PC-38388

Emraclidine

M4 mAChR PAM

Emraclidine (CVL-231) is a potent, selective positive allosteric modulator (PAM) of M4 muscarinic receptor subtype in development for schizophrenia.
PC-73364

VU6019650

M5 mAChR antagonist

VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4.
PC-72979

AZD8871

M3 β2 (MABA)

AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor.
PC-72783

VU6028418

M4 mAChR antagonist

VU6028418 (VU 6028418) is a potent, highly selective, orally bioavailable M4 mAChR antagonist with IC50 of 4.1 nM (hM4).
PC-72662

VU6015241

mAChR4 antagonist

VU6015241 (VU 6015241) is a highly potent and selective antagonist of M4 muscarinic acetylcholine receptor (mAChR4) with IC50 of 71 nM.
PC-72655

HTL9936

M1 mAChR agonist

HTL9936 (HTL-9936) is a potent, selective M1-muscarinic acetylcholine (M1) receptor partial agonist with EC50 of 32 nM.

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