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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU6045422
VU6045422

Chemical Structure : VU6045422

CAS No.: 2851964-55-9

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VU6045422 (VU-6045422)

货号: PC-24341Not For Human Use, Lab Use Only.

VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).
    VU6045422 does not induce a significant long-term depression of fEPSPs in the mouse layer 5 prefrontal cortex.
    VU6045422 was significantly more stable than VU0467319, but was found less stable in liver microsomes.

    物理化学性质&存储条件

    分子量 395.42
    分子式 C22H11D5F2N4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(2,6-difluoro-4-(2-(methyl-d3)-2H-indazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one-7,7-d2

    参考文献

    1. Engers JL, et al. ACS Chem Neurosci. 2025 Mar 25. doi: 10.1021/acschemneuro.5c00119.

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