| Cat. No. |
Product Name |
Information |
| PC-42096 |
DREADD agonist compound 21
hM3Dq agonist
|
DREADD agonist compound 21 (hM3Dq agonist) is a potent, selective human muscarinic acetylcholine M3 receptor (hM3Dq) full agonist with EC50 of 1.7 nM. |
| PC-45939 |
Cevimeline hydrochloride
mAChR M1 agonist
|
Cevimeline hydrochloride is a potent M1-selective muscarinic agonist. |
| PC-45185 |
Clozapine N-oxide
DREADD agonist, M4 mAChR agonist
|
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist, activates the DREADD receptor hM3Dq and hM4Di, a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor agonist with EC50 of 11 nM. |
| PC-43305 |
Batefenterol
MABA, OTUB1 inhibitor
|
Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively, also is a small-molecule inhibitor of deubiquitinase OTUB1 with SPR KD of 23.5 uM. |
| PC-27303 |
Muscarinic antagonist KH-5
Muscarinic antagonist
|
KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors. |
| PC-27274 |
VU6077564
mAChR M1 antagonist
|
VU6077564 is a peripherally restricted and selective mAChR M1 antagonist with IC50 of 31 nM (hM1), >300-fold selective over hM2. |
| PC-26730 |
VU0364572 TFA
M1 muscarinic receptor agonist
|
VU0364572 TFA is a potent, selective, orally active, allosteric agonist of M1 muscarinic receptor with an EC50 of 0.11 uM, shows neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's disease. |
| PC-26504 |
VU6052254
M1 PAM
|
VU6052254 is a potent, selective muscarinic acetylcholine receptor subtype 1 (M1) positive allosteric modulator (PAM) with EC50 of 59 nM. |
| PC-26253 |
VU6025733
M4 mAChR PAM
|
VU6025733 (AG06827) is a highly selective, orally bioavailable M4 muscarinic acetylcholine receptor (M4 mAChR) positive allosteric modulator (PAM) with EC50 of 23 nM and 55 nM for hM4 and rM4 respectively. |
| PC-25835 |
Xanomeline
M1 mAChR agonist
|
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-25834 |
ML-007
M1/M4 mAChR agonist
|
ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors. |
| PC-24948 |
Direclidine
M4 mAChR PAM
|
Direclidine is a selective muscarinic M4 receptor positive allosteric modulator. |
