| Cat. No. |
Product Name |
Information |
| PC-23643 |
TAK‐071
M1 mAChR PAM
|
TAK-071 is a potent and highly selective positive allosteric modulator of M1 muscarinic acetylcholine receptor with EC50 of 520 nM. |
| PC-23642 |
BQCA
M1 mAChR PAM
|
BQCA is a highly selective positive allosteric modulator (PAM) of M1 mAChR with EC50 of 267 nM, shows high intrinsic M1 agonist activity. |
| PC-23641 |
VU0467319
M1 mAChR PAM
|
VU0467319 (VU319) is a potent, selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 492 nM, with minimal M1 agonism (EC50 > 30 uM). |
| PC-23594 |
ADS10227
M2R/M4R antagonist
|
ADS10227 is a potent muscarinic receptor antagonist with binding Ki of 2.8 nM and 5.1 nM for human muscarinic M2 and M4 receptors (hM2R and hM4R) respectively. |
| PC-23358 |
BAY 2413555
M2 mAChR PAM
|
BAY 2413555 is a potent, selective positive allosteric modulator of M2 muscarinic acetylcholine receptor (M2 mAChR, M2R) with EC50 of 2.0 nM in functional M2-GIRK assays. |
| PC-23330 |
Pirenzepine
M1 mAChR antagonist
|
Pirenzepine (LS519, Pirenzepin, Gastrozepin) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist, shows gastric secretion-inhibitory action but without central-nervous sedation. |
| PC-23023 |
Darifenacin
CHI3L1 inhibitor, M3 mAChR inhibitor
|
Darifenacin (UK-88525) is a potent, selective M3 muscarinic receptor antagonist with pKi of 8.9, also inhibits CHI3L1(Chitinase 3-like 1) and PDAC cell growth. |
| PC-22961 |
VU6007496
M1 mAChR PAM
|
VU6007496 is a highly selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 228 nM (hM1), with minimal M1 agonism (EC50>10 μM). |
| PC-22893 |
VU6036864
M5 mAChR antagonist
|
VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors. |
| PC-22795 |
PIPE-307
M1 mAChR antagonist
|
PIPE-307 is a potent, selective, orally bioavailable, brain-penetrant antagonist of M1 muscarinic acetylcholine receptor (M1R, M1 mAChR) with Ki of 4.6 nM in membranes overexpressing human M1R. |
| PC-22509 |
CHF-6550
MABA
|
CHF-6550 is a potent, dual acting muscarinic M3 antagonist and β2 agonist (MABA) with pKi values of 9.3 and 10.6 for M3 and β2 receptor, respectively. |
| PC-21369 |
VU 0365114
M5 mAChR PAM
|
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors. |
