Muscarinic antagonist KH-5

Chemical Structure : Muscarinic antagonist KH-5

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货号: PC-27303Not For Human Use, Lab Use Only.

KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KH-5 is a M1-preferring long-acting muscarinic antagonist (LAMA), functions as a dualsteric PAM antagonist at the M1 receptor, KH-5 behaves mainly as a competitive antagonist at M2 receptors.
KH-5 antagonised responses to multiple agonists in a saturable and probe-dependent manner, but does not decrease maximal response to agonists, contradicting simple allosteric antagonism.
KH-5 does not bind to the classical muscarinic allosteric site at the second extracellular loop but interacted with an extracellular vestibule site.

物理化学性质&存储条件

分子量	473.40
分子式	C21H32INO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-{2-[4-(hexyloxy)benzoyloxy]ethyl}-1-methyl-1,2,3,6-tetrahydropyridin-1-ium iodine

参考文献

1. Janoušková-Randáková A, et al. Biomed Pharmacother. 2025 Apr;185:117977.