| Cat. No. |
Product Name |
Information |
| PC-27274 |
VU6077564
mAChR M1 antagonist
|
VU6077564 is a peripherally restricted and selective mAChR M1 antagonist with IC50 of 31 nM (hM1), >300-fold selective over hM2. |
| PC-26730 |
VU0364572 TFA
M1 muscarinic receptor agonist
|
VU0364572 TFA is a potent, selective, orally active, allosteric agonist of M1 muscarinic receptor with an EC50 of 0.11 uM, shows neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer's disease. |
| PC-26504 |
VU6052254
M1 PAM
|
VU6052254 is a potent, selective muscarinic acetylcholine receptor subtype 1 (M1) positive allosteric modulator (PAM) with EC50 of 59 nM. |
| PC-26253 |
VU6025733
M4 mAChR PAM
|
VU6025733 (AG06827) is a highly selective, orally bioavailable M4 muscarinic acetylcholine receptor (M4 mAChR) positive allosteric modulator (PAM) with EC50 of 23 nM and 55 nM for hM4 and rM4 respectively. |
| PC-25835 |
Xanomeline
M1 mAChR agonist
|
Xanomeline (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens). |
| PC-24948 |
Direclidine
M4 mAChR PAM
|
Direclidine is a selective muscarinic M4 receptor positive allosteric modulator. |
| PC-24879 |
VU6008055
M4 mAChR PAM
|
VU6008055 (AF98943) is a potent, highly selective, orally bioavailable M4 muscarinic acetylcholine receptor positive allosteric modulator with EC50 of 73.4 nM and 19.5 nM for human and rat M4 receptor respectively. |
| PC-24783 |
AC-42
M1 mAChR agonist
|
AC-42 is a poent selective allosteric agonist of M1 muscarinic receptor with EC50 of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. |
| PC-24782 |
77-LH-28-1
M1 mAChR agonist
|
77-LH-28-1 is a potent, selective, CNS penetrant, and M1 muscarinic receptor agonist, potently stimulates intracellular calcium mobilization in CHO-hM1 cells with pEC50 value of 8.1. |
| PC-24345 |
ML293
M4 mAChR PAM
|
ML293 is a selective, brain penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 1.3M (hM4), selective against the four other muscarinic subtypes. |
| PC-24344 |
ML253
M4 mAChR PAM
|
ML253 (VU0448088) is a potent, selective, CNS-penetrant M4 mAChR positive allosteric modulator (PAM) with EC50 of 56 nM (hM4) and 176 nM (rM4), selective against the four other muscarinic subtypes. |
| PC-24343 |
VU6008677
M4 mAChR PAM
|
VU6008677 is a potent, selective M4 mAChR positive allosteric modulator (PAM) with EC50 of 163 nM (hM4), inactive against hM2. |
