Batefenterol |CAS:743461-65-6 Probechem Biochemicals

Chemical Structure : Batefenterol

CAS No.: 743461-65-6

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Batefenterol (GSK961081;TD-5959)

货号: PC-43305Not For Human Use, Lab Use Only.

Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Batefenterol (GSK961081, TD-5959) is a bifunctional M3 mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi/pEC50 of 8.7/9.6 for hM3/hβ2 respectively.
Batefenterol shows weak effect on β1.
Batefenterol is the first MABA compound to enter clinical trials and demonstrate proof of concept and efficacy in COPD.

物理化学性质&存储条件

分子量	740.2438
分子式	C40H42ClN5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mM
Chemical Name/SMILES	Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester

参考文献

1. Hughes AD, et al. J Med Chem. 2015 Mar 26;58(6):2609-22.

2. Ambery C, et al. Drugs R D. 2015 Sep;15(3):281-91.

3. Ambery C, et al. Clin Pharmacol Drug Dev. 2016 Sep;5(5):399-407.

Batefenterol (GSK961081;TD-5959)

生物&药学活性

物理化学性质&存储条件

参考文献

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Batefenterol (GSK961081;TD-5959)

生物&药学活性

物理化学性质&存储条件

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